Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfate → Methyl 1-methoxy-4-bromo-2-naphthoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid | HCID 289393 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Methyl 1-methoxy-4-bromo-2-naphthoate | HCID 12084039 | 78.6% |
반응 단계
A mixture of 4-bromo-1-hydroxy-2-naphthoic acid (compound 67, 24.7 g, 92.2 mmol), dimethyl sulfate (21.8 mL, 231 mmol), and K2CO3 (31.9 g, 231 mmol) in acetone (200 mL) was refluxed overnight. The solid was filtered, and the filtrate was condensed to give a solid residue, which was recrystallized from EtOAc/hexanes to afford the title compound (21.4 g, 78%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541380B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b799a19433b34ef4a7ca626fb9a3a390 |
| 출처 메모 | uspto-grants-2013_09 |