참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | Ethyl Nicotinate | HCID 69188 | — |
| 생성물 | SG 1842 | HCID 571799 | — |
반응 단계
A mixture of ethyl nicotinate (21.9 g.) and ethylenediamine (30 ml.) was heated to 100° C. for 16 hours under an atmosphere of argon. Excess ethylenediamine was removed by distillation in vacuo and the residue was dissolved in water (100 ml.) The insoluble material [bis(carboxamido)derivative] was removed by filtration. Evaporation of the filtrate, addition of toluene (50 ml.) followed by re-evaporation gave crude N-(2-aminoethyl)pyridine-3-carboxamide (26.5 g.) as its oily free base, essentially pure by TLC (SiO2 : 10% MeOH/CHCl3) and which was used without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04520027 |
|---|
| 출처 데이터셋 | uspto-grants-1985_05 |
|---|
| ORD ID | ord-f7aeb0481b594232b94315246dc8c05c |
|---|
| 출처 메모 | uspto-grants-1985_05 |
|---|
