Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 3-Amino-3-(4-chlorophenyl)prop-2-enenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 4-Chlorobenzonitrile | HCID 12163 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 3-Amino-3-(4-chlorophenyl)prop-2-enenitrile | HCID 1484888 | — |
반응 단계
To a mixture of 68.5 g. of p-chlorobenzonitrile and 24.0 g. of sodium hydride (50% in mineral oil) in 250 ml. of ether is added, 26.1 ml. of acetonitrile and 2 ml. of isopropanol. The mixture is stirred and refluxed on a steam bath for 6 hours and then stirred overnight at room temperature. A 5 ml. portion of methanol and 250 ml. of water are added. The ether is boiled away on a steam bath and the mixture is filtered. The solid is dissolved in warm ethyl acetate and filtered. The filtrate is evaporated to a solid giving β-amino-4-chlorocinnamonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04173650 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-b7a1a5518949456f9e3d128f0626a445 |
| 출처 메모 | uspto-grants-1979_11 |