Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Floxuridine → 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Floxuridine | HCID 5790 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1-(Bromomethyl)naphthalene | HCID 137844 | — |
| 생성물 | 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine | HCID 14074406 | 18% |
반응 단계
The general procedures of Reference Examples 4 and 5 were followed using 1.3 g of potassium hydroxide, 1.00 g of 2'-deoxy-5-fluorouridine and 2.7 g of 1-naphthylmethyl bromide, thereby producing 0.28 g of the title compound in a yield of 18%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05155113 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-d6c8084ee8ec40b2a2eb6cbd64127813 |
| 출처 메모 | uspto-grants-1992_10 |