참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 1,1,1-Trimethoxybutane | HCID 123512 | — |
| 반응물 | 2-Chloro-4,5-diamino-6-methylpyrimidine | HCID 275295 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | HCID 19012212 | HCID 19012212 | 47.1% |
반응 단계
A mixture of 2-Chloro-4,5-diamino-6-methylpyrimidine (0.80 g, 5.04 mmol), trimethylorthobutyrate (1.2 ml, 7.6 mmol) and p-TsOH (0.08 g) in 2-methoxyethanol (24 ml) was heated in an oil bath at 140° C. for 24 hours. The product was isolated as described in Step 2 of Example 12 and purified by flash chromatography using EtOAc-hexane (1:1) to give the crystalline titled compound (0.5 g, 47%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05157026 |
|---|
| 출처 데이터셋 | uspto-grants-1992_10 |
|---|
| ORD ID | ord-889a2aec602c401a8cdf19bffb69e9b2 |
|---|
| 출처 메모 | uspto-grants-1992_10 |
|---|
