Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-4-Nitrophenol | HCID 3613389 | — |
| 반응물 | Ethyl 2-chloroethanecarboximidate hydrochloride | HCID 12470659 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(Chloromethyl)-5-nitro-1,3-benzoxazole | HCID 2764189 | — |
반응 단계
2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05158964 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-0c7cdef324e84958856a1348304f2bf5 |
| 출처 메모 | uspto-grants-1992_10 |