Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Toluenesulfonyl chloride → (6R)-8-Oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 7-Aminocephalosporanic acid | HCID 441328 | — |
| 반응물 | (Z)-2-(2-Tritylaminothiazol-4-yl)-2-methoxyiminoacetic acid | HCID 2724510 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | (6R)-8-Oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 52921562 | — |
반응 단계
The process of claim 1 comprising reacting at low temperature in dimethylacetamide, in the presence of triethylamine, tosyl chloride and the syn isomer of 2-(2-tritylamino-4-thiazolyl)-2-methoxyimino-acetic acid and reacting the resulting product with 7-amino-cephalosporanic acid in methylene chloride in the presence of triethylamine to obtain the syn isomer of 3-acetoxymethyl-7-[2-tritylamino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05159070 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-c8c472ccf985436393c06c8da2cb919c |
| 출처 메모 | uspto-grants-1992_10 |