Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide | HCID 86657016 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine | HCID 58445910 | — |
반응 단계
150 mg (0.46 mmol) of N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1) is dissolved in 2 mL methanol and treated with 5 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623627B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-68d246155c0e4a528a24dd8480f2a2ec |
| 출처 메모 | uspto-grants-2014_01 |