Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → Trifluoroacetylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate | HCID 20294522 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Trifluoroacetylpiperazine | HCID 7172020 | — |
반응 단계
To a solution of compound 1c (15.15 g, 53.69 mmol) in CH2Cl2 (60 mL) was added trifluoroacetic acid (18 mL) at room temperature. The mixture was stirred at room temperature for 18 h. The solvent was removed by evaporation. Ether (100 mL) was added to the residue. The white solid was collected by filtration, washed with ether, and dried under vacuum. The crude compound 1d was used in the next reaction without further purification. MS m/z (M+H+) 183.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623858B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-73ee6f5c369b4d6fbb6c6fce896620b0 |
| 출처 메모 | uspto-grants-2014_01 |