Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[3-(Dimethylamino)propyl]piperazine → Ammonia
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[3-(Dimethylamino)propyl]piperazine | HCID 2736234 | — |
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 반응물 | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate | HCID 67217606 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Ammonia | HCID 222 | — |
| 생성물 | N-{[5-({4-[3-(Dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide | HCID 46176152 | — |
반응 단계
The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (30 mg, 0.08 mmol), N,N-dimethyl-3-(piperazin-1-yl)propan-1-amine (27 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623859B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-f7b15319d22847419bcc366178068416 |
| 출처 메모 | uspto-grants-2014_01 |