Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylaluminum → N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-thiadiazole-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 반응물 | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate | HCID 58392977 | — |
| 반응물 | 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamine | HCID 67217191 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-thiadiazole-2-carboxamide | HCID 46175210 | — |
반응 단계
The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate (50 mg, 0.13 mmol), 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamine (110 mg, 0.54 mmol) and trimethylaluminium (2 M in toluene, 0.27 mL) in DCM (10 mL). A portion of the crude product was purified using prep method A, then prep method B.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623859B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-9ad6e38db5de4c079a9ea7af1ea5a6b9 |
| 출처 메모 | uspto-grants-2014_01 |