Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-((1-Methyl-4-piperidinyl)methyl)piperazine → 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-((1-Methyl-4-piperidinyl)methyl)piperazine | HCID 2736942 | — |
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 반응물 | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate | HCID 58392977 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide | HCID 58392987 | — |
반응 단계
The title compound was prepared according to general procedure BK using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate (100 mg, 0.26 mmol), 1-(1-methyl-piperidin-4-ylmethyl)-piperazine (61 mg, 0.31 mmol), trimethylaluminium (2 M in toluene, 0.28 mL) and THF (10 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623859B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-a35e4764f7194401a85b086089a05653 |
| 출처 메모 | uspto-grants-2014_01 |