Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-3-(methylamino)quinolin-4(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1H-Benzotriazole-1-methanol | HCID 224169 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 3-amino-7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoroquinolin-4(1H)-one | HCID 66636886 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-3-(methylamino)quinolin-4(1H)-one | HCID 66636907 | — |
반응 단계
To a 4 ml ethanol solution of 220 mg of 3-amino-7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoroquinolin-4(1H)-one was added 105 mg of 1H-1,2,3-benzotriazol-1-ylmethanol, followed by overnight stirring at room temperature. Next, 48 mg of sodium borohydride was added to the reaction mixture, followed by stirring for 3 hours. By adding water to the resulting reaction mixture and collecting the insoluble materials by filtration, 100 mg of 7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-3-(methylamino)quinolin-4(1H)-one was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08629126B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-f933c727abd14503998f8e75d67f83dd |
| 출처 메모 | uspto-grants-2014_01 |