참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 4-Methyl-3H-benzooxazol-2-one | HCID 12709336 | — |
| 반응물 | 6-Chloropyrimidine-4-carbonyl chloride | HCID 18422098 | — |
| 생성물 | 6-(6-chloropyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one | HCID 58181206 | — |
반응 단계
A well stirred mixture of 2.34 g (13.2 mmol) 6-chloropyrimidine-4-carboxylic acid chloride, 8.00 g (60.0 mmol) aluminium trichloride and 1.79 g (12.0 mmol) 4-methyl-3H-benzoxazol-2-one was heated to 130° C. for 1.5 h. After cooling to RT the mixture was decomposed with ice water, then extracted with ethyl acetate, the organic phase was dried on sodium sulphate and evaporated down i. vac. The crude product left as a solid was triturated with diethyl ether, suction filtered and dried in the air.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08629137B2 |
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| 출처 데이터셋 | uspto-grants-2014_01 |
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| ORD ID | ord-c961173ac0b74a0d908d78f18e71632f |
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| 출처 메모 | uspto-grants-2014_01 |
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