참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Bromopentane | HCID 8057 | — |
| 반응물 | 5-Bromo-1,1,1-trifluoropentane | HCID 580349 | — |
| 반응물 | 1-Chloro-4-acetoxy-9,9,9-trifluorononane | HCID 20386035 | — |
| 반응물 | Ethyl 4-(4-acetyl-8-acetoxy-13,13,13-trifluorotridecyl)benzoate | HCID 20386047 | — |
| 반응물 | Ethyl 4-(4-tert-butoxycarbonyl-5-oxohexyl)benzoate | HCID 20386057 | — |
| 반응물 | 1-Chloro-9,9,9-trifluoro-4-nonanol | HCID 20386099 | — |
| 반응물 | Ethyl 4-(4-acetyl-4-tert-butoxycarbonyl-8-acetoxy-13,13,13-trifluorotridecyl)benzoate | HCID 20386122 | — |
| 반응물 | 1-Chloro-9,9,9-trifluoro-4-nonanone | HCID 20386125 | — |
| 생성물 | 4-(4-Acetyl-8-hydroxy-13,13,13-trifluorotridecyl)benzoic acid | HCID 20386124 | — |
반응 단계
The synthesis of this compound is carried out as described in Example 1, except that in Step B(1) an equivalent amount of 1,1,1-trifluoro-5-bromopentane is substituted for amyl bromide. The product of Step B(1) thus becomes 1-chloro-9,9,9-trifluoro-4-nonanone. Subsequent steps afford in order: Step B(2), 1-chloro-9,9,9-trifluoro-4-nonanol; Step B(3), 1-chloro-4-acetoxy-9,9,9-trifluorononane; Step C, ethyl 4-(4-tert-butoxycarbonyl-5-oxohexyl)benzoate; Step D, ethyl 4-(4-acetyl-4-tert-butoxycarbonyl-8-acetoxy-13,13,13-trifluorotridecyl)benzoate (by substituting 1-chloro-4-acetoxy-9,9,9-trifluorononane for 1-chloro-4-acetoxynonane); Step E, ethyl 4-(4-acetyl-8-acetoxy-13,13,13-trifluorotridecyl)benzoate; and Step F, 4-(4-acetyl-8-hydroxy-13,13,13-trifluorotridecyl)benzoic acid, obtained as a viscous yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04175203 |
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| 출처 데이터셋 | uspto-grants-1979_11 |
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| ORD ID | ord-adef782d75c34c7f9128e415d637ff1b |
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| 출처 메모 | uspto-grants-1979_11 |
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