Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| 반응물 | Oxindole | HCID 321710 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one | HCID 5908088 | 96.1% |
반응 단계
A mixture of oxindole (137 mg, 1.03 mmol), pyrrole-2-carboxaldehyde (115.1 mg, 1.21 mmol) and piperidine (40 μL, 0.404 mmol) in 2.0 mL MeOH was heated at reflux for 3 h. The mixture was cooled in an ice bath and the solid which formed was collected by filtration to give the title compounds (208 mg, 96%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699863B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-464970dcce6d4f16a3ad42e363243763 |
| 출처 메모 | uspto-grants-2004_03 |