Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Chloroethyl chloroformate → 4-Piperidinecarbonitrile hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Chloroethyl chloroformate | HCID 521305 | — |
| 반응물 | 1-Benzylpiperidine-4-carbonitrile | HCID 793383 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 4-Piperidinecarbonitrile hydrochloride | HCID 22744637 | — |
반응 단계
11.0 g of 1-benzyl-4-piperidinecarbonitrile was dissolved in 100 ml 1,2-dichloroethane, 7.1 ml 1-chloroethyl chloroformate was added thereto under ice-cooling. The mixture was stirred at room temperature for 15 min, and then heated under reflux for 1 hr and 20 min. After evaporating, 50 ml methanol was added thereto and it was heated under reflux for 1 hr. The reaction solution was evaporated, and the crystalline residue was washed with ethyl acetate and collected by filtration to give 8.0 g of 4-piperidinecarbonitrile hydrochloride as white crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699870B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-9abad2bad37b48f4ac33a04be491986d |
| 출처 메모 | uspto-grants-2004_03 |