참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 반응물 | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(4-Chloro-3-(trifluoromethyl)phenoxy)benzonitrile | HCID 58046315 | — |
반응 단계
The mixture of 4-chloro-3-(trifluoromethyl)phenol (2 g, 10.18 mmol), K2CO3 (2.109 g, 15.26 mmol) and 4-fluorobenzonitrile (1.232 g, 10.18 mmol) in DMF (20 ml), was heated at 120° C. overnight. It was diluted with water and extracted with EtOAc. The organic phases were collected, washed with water and brine, dried over Na2SO4 and concentrated to afford the title compound as a brown oil. LCMS: rt=3.81 min, [M+H+]=298
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08637536B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-ac89e684849b43549bbc219cda80f47c |
|---|
| 출처 메모 | uspto-grants-2014_01 |
|---|
