참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4'-Fluoroacetophenone | HCID 9828 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-[4-(4-Chloro-3-trifluoromethylphenoxy)-phenyl]-ethanone | HCID 67775020 | 97.4% |
반응 단계
A mixture of 4-chloro-3-(trifluoromethyl)phenol (2 g, 10.18 mmol), 1-(4-fluorophenyl) ethanone (1.406 g) and K2CO3 (2.3 g, 16.64 mmol) in DMF (18 mL) was heated with a microwave condition at 145° C. for 4 h. The solution was diluted with EA and washed with water twice, dried over Na2SO4 and concentrated in vacuo to afford the title compound (3.12 g, 97% yield) as a brown oil. LCMS: rt=3.83 min, [M+H+]=315
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08637536B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-d136af2ecdab44e1b33ffca4552371bf |
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| 출처 메모 | uspto-grants-2014_01 |
|---|
