Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(4-Fluorobenzyloxy)-1h-pyridin-2-one → tert-Butyl 2-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-10-methyl-5,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[2,3-d]azepine-7(6H)-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| 반응물 | tert-butyl 2-bromo-10-methyl-5,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[2,3-d]azepine-7(6H)-carboxylate | HCID 58093388 | — |
| 생성물 | tert-Butyl 2-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-10-methyl-5,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[2,3-d]azepine-7(6H)-carboxylate | HCID 58093323 | 62% |
반응 단계
tert-Butyl 2-bromo-10-methyl-5,8,9,10-tetrahydropyrido[3′,2′:4,5]pyrrolo[2,3-d]azepine-7(6H)-carboxylate (120 mg, 0.316 mmol) and 4-(4-fluorobenzyloxy)pyridin-2(1H)-one (76 mg, 0.35 mmol) were reacted following the procedure for Example 2 (step d) to provide the title compound (100 mg, 62%) as a white solid: ESI MS m/z 519 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637501B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-967e53c24cdd4f3daf2cbaf10b05e8a4 |
| 출처 메모 | uspto-grants-2014_01 |