Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(4-Fluorobenzyloxy)-1h-pyridin-2-one → tert-Butyl 2-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-10-methyl-7,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| 반응물 | tert-butyl 2-bromo-10-methyl-7,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate | HCID 86649551 | — |
| 생성물 | tert-Butyl 2-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-10-methyl-7,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate | HCID 70805211 | 96.4% |
반응 단계
tert-Butyl 2-bromo-10-methyl-7,8,9,10-tetrahydropyrido[3′,2′:4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate (147 mg, 0.386 mmol) and 4-(4-fluorobenzyloxy)pyridin-2(1H)-one (93 mg, 0.43 mmol) were reacted following the procedure for Example 2 (step d) to provide the title compound (193 mg, 96%) as a yellow oil: ESI MS m/z 519 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637501B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-26a3337f07a64d908a49cfc6d6815a66 |
| 출처 메모 | uspto-grants-2014_01 |