Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyl iodide → methyl (5R)-5-((trimethylsilyl)ethynyl)-L-prolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyl iodide | HCID 85247 | — |
| 반응물 | dimethyl(2S,5R)-5-((trimethylsilyl)ethynyl)pyrrolidine-1,2-dicarboxylate | HCID 11161884 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | methyl (5R)-5-((trimethylsilyl)ethynyl)-L-prolinate | HCID 16090847 | — |
반응 단계
A solution of dimethyl(2S,5R)-5-((trimethylsilyl)ethynyl)pyrrolidine-1,2-dicarboxylate (5.43 g, 19.16 mmol) and iodotrimethylsilane (3 mL, 28.74 mmol) in chloroform (100 mL) was heated to 65° C. for 3 hours, was cooled to room temperature, concentrated under reduced pressure and flash chromatographed with 35% ethyl acetate/65% hexane to provide the titled compound. MS (DCI/NH3) m/e 226 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637546B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-536aa212691d4fbf9e505858ef135f9e |
| 출처 메모 | uspto-grants-2014_01 |