Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Bis(trifluoromethyl)benzaldehyde → (7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Bis(trifluoromethyl)benzaldehyde | HCID 2736095 | — |
| 반응물 | Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylate | HCID 86586438 | — |
| 생성물 | (7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine | HCID 60071804 | — |
반응 단계
Using 2,4-bis(trifluoromethyl)benzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 129. LRMS (ES)+: 472.4 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699852B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-a99601a3f01b48718ec216c36a11f79c |
| 출처 메모 | uspto-grants-2004_03 |