Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexyl bromide → 1-Cyclohexyl-2-methylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexyl bromide | HCID 7960 | — |
| 반응물 | Pyrazine | HCID 9261 | — |
| 반응물 | HCID 178424303 | HCID 178424303 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Cyclohexyl-2-methylbenzene | HCID 599938 | 99% |
반응 단계
Bromocyclohexane (81.7 mg, 0.5 mmol) and a THF solution (0.94 mL, 0.80 M, 0.75 mmol) of 2-methylphenylmagnesium bromide were used as starting materials, and reacted as in Entry 1. Conditions: The THF solution of 2-methylphenylmagnesium bromide was added dropwise at 40° C. over 20 minutes. 1H-NMR analysis was conducted using pyrazine (13.2 mg, 0.16 mmol) as an internal standard (yield 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637710B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-1843bf8c1ed5453c846dfb4e2ca277c9 |
| 출처 메모 | uspto-grants-2014_01 |