참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethanamine, 2-chloro-N-methyl-, hydrochloride (1:1) | HCID 3028223 | — |
| 반응물 | HCID 178527925 | HCID 178527925 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Acetone diethylether | HCID 21584533 | — |
| 생성물 | HCID 14126765 | HCID 14126765 | 38.9% |
반응 단계
A solution of 18 g of N-methyl-2-chloroethylamine hydrochloride, 20 g of 3-mercapto-1,2,4-triazolo(4,3-a)pyridine and 40 ml of triethylamine in 150 ml of ethanol is heated under reflux for 2 hours. After evaporation, the residue is taken up in water, 0.1N sodium hydroxide is added and extraction is carried out with chloroform. The chloroform phase is washed with water, dried over sodium sulfate and evaporated to dryness. The residue obtained is dissolved in an ethyl ether/acetone mixture and the solution is acidified by the addition of a solution of ethyl ether saturated with hydrogen chloride gas. The precipitate formed is filtered off, washed with ether and dried to give 12.6 g of 3-[2-(methylamino)ethylmercapto]-1,2,4-triazolo(4,3-a)pyridine hydrochloride in the form of crystals melting at 195°-7° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04886805 |
|---|
| 출처 데이터셋 | uspto-grants-1989_12 |
|---|
| ORD ID | ord-0e5859de25f346cba5278d7a7ea35075 |
|---|
| 출처 메모 | uspto-grants-1989_12 |
|---|
