Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
alpha-Naphthaleneacetic acid, ethyl ester → Diethyl 2-dimethylamino-5-(1-naphthyl)-2,4-hexadienedioate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | alpha-Naphthaleneacetic acid, ethyl ester | HCID 62428 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 86743575 | — |
| 반응물 | Diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate | HCID 86743580 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl 2-dimethylamino-5-(1-naphthyl)-2,4-hexadienedioate | HCID 53994139 | 17.1% |
반응 단계
The procedure is as in Example 2 for the preparation of diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (10 g), a 2M ethanolic solution of sodium ethylate (26 cc) and ethyl 2-(1-naphthyl)acetate (7.5 g) in ethanol (100 cc). After purification by chromatography on a silica column with a mixture of cyclohexane and ethyl acetate (80:20 by volume), diethyl 2-dimethylamino-5-(1-naphthyl)-2,4-hexadienedioate (2.2 g) is obtained in the form of a yellow oil, and is used in the crude state in the subsequent syntheses.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04886835 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-680d84392e4040ff89533067cd470af4 |
| 출처 메모 | uspto-grants-1989_12 |