Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 5-Aminoimidazole-4-carboxamide hydrochloride | HCID 66146 | — |
| 반응물 | 3-Dimethylamino-3'-methoxyacrylophenone | HCID 42573796 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide | HCID 14677474 | 65.2% |
반응 단계
A stirred mixture of 15.0 g of 3-dimethylamino-3'-methoxyacrylophenone (prepared as described in Example 5 and 9.2 g of 4-amino-5-imidazolecarboxamide hydrochloride in 150 ml of glacial acetic acid was heated at reflux for 24 hours. The solvent was evaporated in vacuo and the crystalline residue was treated with 100 ml of saturated sodium bicarbonate solution, filtered and washed with 200 ml of water to give yellow crystals. This material was treated with 400 ml of acetonitrile then with 600 ml of hot ethanol to give 9.9 g of the product of the example as yellow crystals, mp 249°-252° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04888345 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-73767f1bc2024c24a26597c6068287f1 |
| 출처 메모 | uspto-grants-1989_12 |