Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Tolylacetic acid → N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Tolylacetic acid | HCID 248474 | — |
| 반응물 | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| 생성물 | N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester | HCID 22492098 | — |
반응 단계
Following General Procedure B and using 4-methylphenylacetic acid (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example B above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl. s.NMR data was as follows:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642261B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-f93afcb160fa4e3683ab033fb799dd80 |
| 출처 메모 | uspto-grants-2003_11 |