Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3,3-Diethoxypropyl)tetrahydropyrimidin-2-one → 3-(2-Oxo-tetrahydropyrimidin-1-yl)propionaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3,3-Diethoxypropyl)tetrahydropyrimidin-2-one | HCID 69224786 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(2-Oxo-tetrahydropyrimidin-1-yl)propionaldehyde | HCID 84032626 | 67.7% |
반응 단계
A mixture of 1-(3,3-diethoxypropyl)-tetrahydropyrimidin-2-one (1 g, 4.35 mmole), and 1.0 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, the filtrate was concentrated and the residue dissolved in dichloromethane (30 mL), dried with magnesium sulfate, and concentrated to give 3-(2-oxo-tetrahydropyrimidin-1-yl)-propionaldehyde (0.46 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06645958B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-e32ee6ad76ff41de888dd4dc97a08188 |
| 출처 메모 | uspto-grants-2003_11 |