Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-Bromo-3-(2-triisopropylsilyloxy-ethoxy)-naphtalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromo-2-naphthol | HCID 12115596 | — |
| 반응물 | Silane, (2-bromoethoxy)tris(1-methylethyl)- | HCID 12137438 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Bromo-3-(2-triisopropylsilyloxy-ethoxy)-naphtalene | HCID 12115597 | — |
반응 단계
A stirred mixture of 4.38 g (19.6 mmol) of 1-bromo-naphtalen-3-ol (prepared according to the procedure of M. S. Newman, V. Sankaran, D. R. Olson, J. Am. Chem. Soc. 1976, 98, 3237-3242), 5.52 g (19.6 mmol) of 1-bromo-2-triisopropylsilyloxy-ethane, 13.56 g (98.1 mmol) of potassium carbonate and 1.45 g (3.9 mmol) of tetrabutylammonium iodide in 50 mL of dimethylformamide is heated to 60° C. for 4 hours. Then an additional 0.55 g (2.0 mmol) of 1-bromo-2-triisopropylsilyloxy-ethane are added and stirring is continued for another hour at 60° C., after which TLC analysis indicated complete consumption of 1-bromo-naphtalen-3-ol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06645970B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-e8650296282a450a94feaa31f617cf6a |
| 출처 메모 | uspto-grants-2003_11 |