참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 1-(3,4-Dichlorophenyl)-2-hydroxyethan-1-one | HCID 7062193 | — |
| 반응물 | Potassium cyanate | HCID 11378442 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(3,4-Dichlorophenyl)-2-oxazolone | HCID 12992960 | 52% |
반응 단계
A mixture of 2-hydroxy-3′,4′-dichloroacetophenone (10.3 g), potassium cyanate (8.1 g) and 2-propanol (100 mL) was heated to 50° C., and acetic acid (6.0 g) was slowly added dropwise. The mixture was stirred at 50° C. for 2 h. The reaction mixture was concentrated and poured into iced water (200 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (6.0 g, 52%). Recrystallization from tetrahydrofuran-hexane gave pale-yellow prism crystals. melting point: 262-263° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06699995B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-f9b40148f4db4f7fb5c5398439a6374c |
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| 출처 메모 | uspto-grants-2004_03 |
|---|
