Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methoxyacetyl chloride → HCID 53812669, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methoxyacetyl chloride | HCID 96623 | — |
| 반응물 | N-(1-Boc-piperidin-3-ylmethyl)aniline | HCID 12972131 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 53812669 | HCID 53812669 | 56% |
반응 단계
To a stirred suspension of N-(1-Boc-piperidin-3-ylmethyl)-aniline 4 (101 mg, 0.348 mmol) and piperidinomethyl polystyrene resin (110 mg) in 2 mL of dry CH2Cl2 was added methoxyacetyl chloride (97%, 34 μL, 1.05 eq.) at room temperature. After being shaken at room temperature for 4 hours, the reaction mixture was passed through an aminopropyl NH2 cartridge and washed with CH2Cl2 Removal of CH2Cl2 afforded methoxyacetic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenylamide 38 (70 mg, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06645980B1 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-414e8e757fe842bd9d72a4f70af5b91d |
| 출처 메모 | uspto-grants-2003_11 |