참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-[4-(3-Aminophenyl)piperazin-1-yl]ethan-1-one | HCID 11117539 | — |
| 반응물 | Ethyl 2,4-difluoro-5-nitrobenzoate | HCID 22330120 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | Ethyl 4-(3-(4-acetyl-1-piperazinyl)-phenyl)-amino-6-fluoro-3-nitrobenzoate | HCID 86592319 | — |
반응 단계
A mixture of ethyl 2,4difluoro-5-nitrobenzoate (22) (1.0 g; 4.33 mmol), 4f (0.95 g; 4.33 mmol) and triethylamine (0.6 ml; 0.33 mmol) in anhydrous NMP (10 ml) was heated to 80° C. for one hour. The cooled mixture was poured into water and extracted with ethyl acetate. The organic extract was dried over magnesium sulphate, concentrated under reduced pressure and purified by column-chromatography on silica gel using ethyl acetate as the eluent. Yield: 1.53 g (82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06649609B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-f60e53fbf16d4216930254366e7b9374 |
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| 출처 메모 | uspto-grants-2003_11 |
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