Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Catechol → 2,3-Dihydro-2,2-dimethyl-7-benzofuranol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Catechol | HCID 289 | — |
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | 3-Chloro-2-methyl-1-propene | HCID 11241 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,3-Dihydro-2,2-dimethyl-7-benzofuranol | HCID 15278 | — |
| 생성물 | 7-Methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran | HCID 13531377 | — |
반응 단계
The starting material 2,3-dihydro-2,2-dimethyl-7-benzofuranol is prepared from catechol and 3-chloro-2-methylpropene as described by Neth. No. 6,500,340. The material (16.4 g) is added to 125 ml of water and contacted with 8 ml of 50% NaOH. After stirring one-half hour, 16.4 g of dimethylsulfate is added and the resulting suspension is stirred and heated at 60° for 2 hours. The resulting mixture is extracted with methylene chloride. The organic phase is dried over sodium sulfate and the solvent is evaporated under reduced pressure. The residual oil is distilled to afford 2,3-dihydro-2,2-dimethyl-7-methoxybenzofuran.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04576632 |
| 출처 데이터셋 | uspto-grants-1986_03 |
| ORD ID | ord-cde4ca8fb730469395b1c40d09defc1a |
| 출처 메모 | uspto-grants-1986_03 |