Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 4-(2-Indanylamino)-5-isopropylthieno[2,3-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 2-Aminoindan hydrochloride | HCID 122764 | — |
| 반응물 | HCID 178439799 | HCID 178439799 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(2-Indanylamino)-5-isopropylthieno[2,3-d]pyrimidine | HCID 22719603 | 62.1% |
반응 단계
Using 4-hydroxy-5-isopropylthieno[2,3-d]pyrimidine (200 mg, 1.03 mmol), phosphorus oxychloride (1.0 ml), 2-aminoindan hydrochloride (200 mg, 1.2 mmol), triethylamine (1.0 ml, 7.2 mmol) and dry ethanol (5 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (190 mg, 0.64 mmol) having the following physical properties:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06703421B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-10d44b48026c4aa6a2fc4f8b677a718c |
| 출처 메모 | uspto-grants-2004_03 |