Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 4-[5-[(E)-2-(4-Methylphenyl)ethenyl]indan-2-yl]amino-5-methylthieno[2,3-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Chloro-5-methylthieno[2,3-d]pyrimidine | HCID 290225 | — |
| 반응물 | 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride | HCID 22719590 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-[5-[(E)-2-(4-Methylphenyl)ethenyl]indan-2-yl]amino-5-methylthieno[2,3-d]pyrimidine | HCID 12094068 | 58.3% |
반응 단계
Using 2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol), ethanol (0.6 ml), triethylamine (50 μl, 0.36 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (11 mg, 0.060 mmol), a similar procedure to b) in Production Example 208 was carried out The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=4:1) to obtain the title compound (14 mg, 0.035 mmol) having the following physical properties:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06703421B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-134ae1cc6abb455f8150da7402ee78a5 |
| 출처 메모 | uspto-grants-2004_03 |