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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 48425생성일: 2026년 10월 24일

Triethylamine → 4-[5-[(E)-2-(4-Methylphenyl)ethenyl]indan-2-yl]amino-5-methylthieno[2,3-d]pyrimidine

https://huagongshe.com/ko/reaction/48425

반응식

참여 물질

역할이름HCID투입량
반응물TriethylamineHCID 8471—
반응물4-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 290225—
반응물2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochlorideHCID 22719590—
용매EthanolHCID 702—
생성물4-[5-[(E)-2-(4-Methylphenyl)ethenyl]indan-2-yl]amino-5-methylthieno[2,3-d]pyrimidineHCID 1209406858.3%

반응 단계

Using 2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol), ethanol (0.6 ml), triethylamine (50 μl, 0.36 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (11 mg, 0.060 mmol), a similar procedure to b) in Production Example 208 was carried out The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=4:1) to obtain the title compound (14 mg, 0.035 mmol) having the following physical properties:

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06703421B1
출처 데이터셋uspto-grants-2004_03
ORD IDord-134ae1cc6abb455f8150da7402ee78a5
출처 메모uspto-grants-2004_03