Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Iodohexane → 5-(Hexyloxy)-2-methyl-1H-indole-3-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Iodohexane | HCID 12527 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | O-Desmethyl-N-deschlorobenzoyl Indomethacin | HCID 11310252 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-(Hexyloxy)-2-methyl-1H-indole-3-acetic acid | HCID 19935757 | 62% |
반응 단계
To a solution of 5-hydroxy-2-methyl-1H-indole-3-acetic acid (7.17 g, 35.0 mmol) in methanol (40 mL) is added sodium methoxide (70 mmol). The solution is evaporated, dimethylformamide (40 mL) is added followed by hexyl iodide (35.0 mmol). After 2 days the solvent is removed and the residue is partitioned between ethyl acetate and pH=4 buffer. The organic layer is separated, dried over MgSO4 and evaporated to 8.6 g of a brown solid. Recrystallization from ethanol/water affords 6.23 g (62%) of white crystals, m.p. 65°-67° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05229516 |
| 출처 데이터셋 | uspto-grants-1993_07 |
| ORD ID | ord-1e2dbac9c99d4930a37317edb68511d2 |
| 출처 메모 | uspto-grants-1993_07 |