Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl bromoacetate → Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6,7-Dichloro-1-benzothiophene-5-ol | HCID 13289997 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate | HCID 13289999 | 63.8% |
반응 단계
A mixture of 3.6 g of 6,7-dichloro-5-hydroxybenzo[b]thiophene, 3.0 g of ethyl bromoacetate, 1.5 g of potassium carbonate and 40 ml of anhydrous dimethylformamide is stirred at 70°-80° for 16 hours. The cooled mixture is diluted with ice-water (200 g) and the solid collected by filtration. Recrystallization of the crude product from acetone-hexane gives 3.2 g of ethyl [(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate as yellowish needles, mp 92°-93°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04537976 |
| 출처 데이터셋 | uspto-grants-1985_08 |
| ORD ID | ord-1930dce74430403d89f3c7b8d41e4795 |
| 출처 메모 | uspto-grants-1985_08 |