Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3,4-Difluoro-4'-ethoxytolan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1,2-Difluoro-4-iodobenzene | HCID 2724444 | — |
| 반응물 | 1-Ethoxy-4-ethynylbenzene | HCID 2775124 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 3,4-Difluoro-4'-ethoxytolan | HCID 67857987 | — |
반응 단계
0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242618 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-c11e140ba9cd45de8bbf75d1cbd64d0a |
| 출처 메모 | uspto-grants-1993_09 |