Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl imidazo[1,2-a]pyridine-6-carboxylate → 1-tert-butyl-6-pyridin-4-yl-3-(pyridin-4-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl imidazo[1,2-a]pyridine-6-carboxylate | HCID 11830209 | — |
| 반응물 | 1-tert-butyl-3-(4-pyridylmethyl)-5-amino-1H-pyrazole-4-carboxamide | HCID 19432840 | — |
| 반응물 | 5-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide | HCID 22449352 | — |
| 생성물 | 1-tert-butyl-6-pyridin-4-yl-3-(pyridin-4-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one | HCID 178448765 | 84% |
반응 단계
Following a procedure substantially similar to that described in Example 16, part c, but substituting ethyl isonicotinate for 6-carboethoxyimidazo[1,2-a]pyridine and 1-tert-butyl-3-(4-pyridylmethyl)-5-amino-1H-pyrazole-4-carboxamide for 1-cyclopentyl-3-ethyl-5-amino-1H-pyrazole-4-carboxamide there was obtained 1-tert-butyl-3-(4-pyridylmethyl)-6-(4-pyridyl)-pyrazolo[3,4-d]pyrimidin-4-one in 84% yield as a white powder, m.p. 233°-235° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05294612 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-df1378e2cfcf4f3cbaf8f63c366b4341 |
| 출처 메모 | uspto-grants-1994_03 |