참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Bromopyridine | HCID 12286 | — |
| 반응물 | (2R)-pent-4-en-2-ol | HCID 6999724 | — |
| 촉매 | Tri-o-tolylphosphine | HCID 80271 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (2R)-(4E)-5-(3-pyridyl)4-penten-2-ol | HCID 66745560 | 65.2% |
반응 단계
A mixture of 3-bromopyridine (9.17 g, 58.04 mmol), (2R)-4-penten-2-ol (6.00 g, 69.65 mmol), palladium(II) acetate (130 mg, 0.58 mmol), tri-o-tolylphosphine (710 mg, 2.32 mmol), triethylamine (34.7 mL, 249.5 mmol), and acetonitrile (35 mL) were heated in a sealed glass tube at 140° C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3×200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give 6.17 g (65.2%) of a pale-yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06979695B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_12 |
|---|
| ORD ID | ord-3734bd6563844b058ed6bd49d61cfd10 |
|---|
| 출처 메모 | uspto-grants-2005_12 |
|---|
