참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione | HCID 11470572 | — |
| 반응물 | 1-(2,5-Difluorophenyl)piperazine | HCID 18545281 | — |
| 생성물 | HCID 57245937 | HCID 57245937 | 32% |
반응 단계
A mixture of 1-(2,5-difluorophenyl)piperazine (20 mg, 0.10 mmol) and (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione (20 mg, 0.082 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (10.8 mg, 0.026 mmol, 32%): ESI-MS m/z 406 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06706716B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-81bb182d02b04dfa85b91303e5259195 |
|---|
| 출처 메모 | uspto-grants-2004_03 |
|---|
