Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Diethyl 2-carboxybenzylphosphonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Phosphonic acid, P-((2-methylphenyl)methyl)-, diethyl ester | HCID 112945 | — |
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Diethyl 2-carboxybenzylphosphonate | HCID 11369294 | — |
반응 단계
4 g of diethyl 2-methylbenzylphosphonate were added to a solution of 12 g of KMnO4 and 4 g of Na2CO3 in 300 ml of water and the mixture was boiled under reflux for 24 hours. It was acidified with 15 ml of concentrated H2SO4 and extracted five times with 300 ml of ether each time. The organic phase was dried over MgSO4, the solvent was evaporated off on a rotary evaporator and the residue was chromatographed over silica gel (CH2Cl2 /methanol/triethylamine 9/1/0.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242908 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-3b1908a01a5143ef967011e4244289b7 |
| 출처 메모 | uspto-grants-1993_09 |