Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 3-(4,6-Dimethoxypyrimidine-2-yl)-5-methoxy-2-methylindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-Methoxyphenylhydrazine hydrochloride | HCID 2723904 | — |
| 반응물 | 1-(4,6-Dimethoxypyrimidin-2-yl)propan-2-one | HCID 11264052 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(4,6-Dimethoxypyrimidine-2-yl)-5-methoxy-2-methylindole | HCID 17856763 | 67% |
반응 단계
To 80 ml of toluene were added 8.0 g (40 m moles) of 1-(4,6-dimethoxypyrimidine-2-yl)-2-propanone and 7.7 g (44 m moles) of 4-metoxyphenylhydrazine hydrochloride. Thereto was added 6.0 g (44 m moles) of zinc chloride. Refluxing was made for 2 hours with heating. The reaction mixture was allowed to cool. Thereto were added ethyl acetate and water to dissolve the whole reaction mixture. The oily layer was washed with water, separated and dried over Glauber's salt. The resulting organic layer was concentrated under reduced pressure using an rotary evaporator to obtain, as an orange solid, 8.0 g (26.7 m moles) of 3-(4,6-dimethoxypyrimidine-2-yl)-5-methoxy-2-methylindole. Yield: 67% Recrystallization from toluene was made.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07531654B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-f874ce1897784008bb6ea42e66a46d75 |
| 출처 메모 | uspto-grants-2009_05 |