Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dioxane hydrochloride → 4,4-Difluoroproline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | (2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropyrrolidine-2-carboxylic acid | HCID 22977458 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4,4-Difluoroproline | HCID 15216102 | — |
반응 단계
To a solution of (S)-1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid (500 mg, 1.99 mmol) in methanol (30 mL) was added 4N HCl dioxane (3 mL). The reaction mixture was stirred at rt for 6 h. Concentration gave an oil which was used for the next step without purification (480 mg, 100%). 1H NMR (CD3OD, 400 MHz) δ 4.76 (1H, t, J=8.5 Hz), 3.79-3.87 (2H, m), 2.91-3.03 (1H, m), 2.73-2.82 (1H, m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07534792B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-ca2dafbad2b146b187da2d8430449be6 |
| 출처 메모 | uspto-grants-2009_05 |