Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid → 1-Benzyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid | HCID 55251 | — |
| 반응물 | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)piperidine | HCID 22995692 | 90.7% |
반응 단계
4′-Trifluoromethyl-biphenyl-carboxylic acid (5.0 g) was dissolved in dimethylformamide (50 mL), and to this solution were added at room temperature 4-amino-1-benzylpiperidine (3.55 g), 1-hydroxybenzotriazole hydrate (3.0 g) and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (3.58 g). The mixture was stirred at room temperature overnight, and the reaction solution was concentrated in vacuo to precipitate crystals. The crystals were washed successively with saturated aqueous sodium bicarbonate and water, and dried in vacuo to give the title compound (7.42 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07538140B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-a99ba96bcbe94e9f809d866deea4b699 |
| 출처 메모 | uspto-grants-2009_05 |