Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluoroaniline → Diisopropyl Ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluoroaniline | HCID 9731 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1-Acetylpiperidine-4-carboxylic acid | HCID 117255 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | 1-Acetyl-4-(4-fluorophenyl)-carbamoylpiperidine | HCID 22741829 | — |
반응 단계
A mixture of N-acetylpiperidine-4-carboxylic acid (514 mg), 1-hydroxybenzotriazole (405 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (575 mg) and 4-fluoroaniline (284.2 ml) in dichloromethane (5 ml) was stirred for 18 hours at ambient temperature. The mixture was diluted with dichloromethane and washed with water, saturated aqueous sodium hydrogen carbonate, water, and brine. After drying with magnesium sulfate, the solvents were removed under reduced pressure. A residue was purified by column chromatography (silica gel 40 ml, dichloromethane:methanol=15:1). After trituration with diisopropyl ether, 1-acetyl-4-(4-fluorophenyl)-carbamoylpiperidine (532 mg) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710043B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-7d7f0fcf5281400cbfb6b320c8612b93 |
| 출처 메모 | uspto-grants-2004_03 |