Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → [4-(Morpholin-4-yl)phenyl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 4-(Morpholin-4-yl)benzoic acid | HCID 345278 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [4-(Morpholin-4-yl)phenyl]methanol | HCID 2776456 | 18% |
반응 단계
A solution of 4-(4-morpholinyl)benzoic acid (1.00 g, 4.83 mmol) and 4-methylmorpholine (0.53 mL, 4.8 mmol) in tetrahydrofuran (25 mL) at −10° C. was treated with ethyl chloroformate (0.46 mL, 4.8 mmol). After 0.25 h, the mixture was treated with sodium borohydride (550 mg, 14.5 mmol) followed by MeOH (50 mL) slowly. The mixture was then treated with 5% HOAc in water and the mixture was concentrated. The residue was purified by chromatography (SiO2, EtOAc:hexanes) yielding 164 mg (18%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710057B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-5fc4285abbbc4150bb295b67846ad02a |
| 출처 메모 | uspto-grants-2004_03 |