Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester → {5-Chloro-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester | HCID 69486803 | — |
| 반응물 | (2-Amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69489727 | — |
| 생성물 | {5-Chloro-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester | HCID 86589288 | — |
반응 단계
The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J19) (311 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a yellow oil (420 mg, 79%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06949542B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-c8dfb819b74545f6b02eec4aea7964e6 |
| 출처 메모 | uspto-grants-2005_09 |