Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acryloyl chloride → 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acryloyl chloride | HCID 13140 | — |
| 반응물 | Methacryloyl chloride | HCID 13528 | — |
| 반응물 | 5,5,5-Trifluoro-4-(trifluoromethyl)pentane-1,4-diol | HCID 21895362 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 반응물 | HCID 178418348 | HCID 178418348 | — |
| 생성물 | 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate | HCID 58999836 | 86% |
반응 단계
1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl acrylate was synthesized according to the method of Example 4 but substituting (a) 60 g (0.25 mol) of 1,1,1-trifluoro-2-trifluoromethyl-4-methyl-2,5-pentanediol (2) for diol (4), (b) 311 mL (0.497 mol) of methyllithium (1.6M in ether) for the n-butyllithium, and (c) 22.3 g (0.248 mol) of acryloyl chloride for the methacryloyl chloride, to yield 58 g (86%) of the title compound as a clear colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07767866B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-93decf45e0204c098bca0e169fb3c16c |
| 출처 메모 | uspto-grants-2010_08 |